Oscar Busnadiego Selected Research

N- methyl- N- (3- ((2- (2- oxo- 2,3- dihydro- 1H- indol- 5- ylamino)- 5- trifluoromethyl- pyrimidin- 4- ylamino)- methyl)- pyridin- 2- yl)- methanesulfonamide

12/2012	Adenoviral gene transfer of endothelin-1 in the lung induces pulmonary fibrosis through the activation of focal adhesion kinase.
5/2012	Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation.

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Oscar Busnadiego Research Topics

Disease

7	Fibrosis (Cirrhosis) 01/2016 - 03/2010
2	Cicatrix (Scar) 01/2015 - 03/2010
1	Hypoxia (Hypoxemia) 01/2016
1	Myocardial Infarction 01/2016
1	Infarction (Infarctions) 01/2016
1	Ascending Aorta Aneurysm 04/2015
1	Marfan Syndrome (Marfan's Syndrome) 04/2015
1	Aortic Aneurysm (Aneurysm, Aortic) 04/2015
1	Inflammation (Inflammations) 01/2015
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/2012
1	Atherosclerosis 06/2011
1	Vascular Remodeling 06/2011
1	Hypertension (High Blood Pressure) 06/2011
1	Wounds and Injuries (Trauma) 03/2010

Drug/Important Bio-Agent (IBA)

3	Bleomycin (Blenoxane)FDA LinkGeneric 01/2016 - 03/2010
3	Endothelin-1 (Endothelin 1)IBA 01/2015 - 03/2010
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2016 - 04/2015
2	Proteins (Proteins, Gene)FDA Link 01/2016 - 03/2010
2	CollagenIBA 01/2016 - 12/2012
2	Vasoconstrictor AgentsIBA 01/2015 - 06/2011
2	Bosentan (Tracleer)FDA Link 01/2015 - 03/2010
2	N- methyl- N- (3- ((2- (2- oxo- 2,3- dihydro- 1H- indol- 5- ylamino)- 5- trifluoromethyl- pyrimidin- 4- ylamino)- methyl)- pyridin- 2- yl)- methanesulfonamideIBA 12/2012 - 05/2012
2	Focal Adhesion Protein-Tyrosine KinasesIBA 12/2012 - 05/2012
1	Neutralizing AntibodiesIBA 01/2016
1	Oxidoreductases (Dehydrogenase)IBA 01/2016
1	AminopropionitrileIBA 01/2016
1	Protein Isoforms (Isoforms)IBA 01/2016
1	myocardinIBA 04/2015
1	Transcription Factors (Transcription Factor)IBA 04/2015
1	2-methylcyclopentadienyl manganese tricarbonyl (MMT)IBA 01/2015
1	macitentanIBA 01/2015
1	Peptides (Polypeptides)IBA 01/2015
1	Small Interfering RNA (siRNA)IBA 05/2012
1	Biological ProductsIBA 06/2011
1	Biological FactorsIBA 06/2011
1	Transforming Growth Factor beta1 (TGF beta 1)IBA 03/2010
1	4- (4- (3- (pyridin- 2- yl)- 1H- pyrazol- 4- yl)pyridin- 2- yl)- N- (tetrahydro- 2H- pyran- 4- yl)benzamideIBA 03/2010

Therapy/Procedure

1	Peritoneal Dialysis 01/2015